Question

What is the use of Plavix and aspirin after post-operative CABG?

1) To prevent blood clots
2) To reduce inflammation
3) To control pain
4) To lower blood pressure

Answer 1

The primary use of Plavix and aspirin after post-operative CABG is to prevent blood clots. Thus the correct option is (1).

Step-by-step explanation:

After coronary artery bypass grafting (CABG) surgery, patients are at an increased risk of developing blood clots. Plavix (clopidogrel) and aspirin are prescribed to prevent the formation of these clots. Blood clots can lead to serious complications such as myocardial infarction or stroke, which is why antiplatelet medications are crucial in post-operative care. By inhibiting platelet aggregation, Plavix and aspirin help maintain the patency of the grafts and prevent occlusion of blood vessels.

Platelets play a key role in the clotting process by adhering to each other and forming clumps. Plavix acts by inhibiting platelet aggregation through the adenosine diphosphate (ADP) pathway, while aspirin inhibits platelet aggregation by blocking the cyclooxygenase (COX) pathway. Together, these medications provide dual antiplatelet therapy, offering a more comprehensive approach to preventing clot formation. This dual therapy is particularly important in the post-operative period, given the stress placed on the cardiovascular system during surgery and the vulnerability of newly grafted vessels.

It's important to note that Plavix and aspirin are not used for reducing inflammation, controlling pain, or lowering blood pressure after post-operative CABG. Their primary function is to address the increased risk of blood clotting associated with the surgical procedure. The use of these medications is a well-established and evidence-based practice in cardiovascular care, contributing to improved outcomes and reduced complications in patients undergoing CABG surgery.

Answer 2

The primary use of Plavix and aspirin after post-operative CABG is to prevent blood clots. Thus the correct option is (1).

Step-by-step explanation:

Post-operative Coronary Artery Bypass Grafting (CABG) is a surgical procedure used to improve blood flow to the heart. The administration of Plavix (clopidogrel) and aspirin is a standard practice to prevent blood clot formation. Both medications belong to the antiplatelet class and work synergistically to inhibit platelet aggregation, reducing the risk of thrombosis.

Platelets play a crucial role in clot formation by adhering to each other and to the damaged vessel wall. Aspirin inhibits the enzyme cyclooxygenase, reducing the production of thromboxane A2, a potent platelet aggregator. Plavix, on the other hand, inhibits platelet activation by blocking the ADP receptor. By combining these medications, the antiplatelet effect is enhanced, providing a more comprehensive approach to preventing clot formation in the coronary arteries post-CABG.

It's important to note that Plavix and aspirin are not prescribed primarily for reducing inflammation, controlling pain, or lowering blood pressure in the post-operative CABG setting. Their mechanism of action is centered around antiplatelet activity, making them effective in preventing complications related to thrombosis. As with any medication, the decision to use Plavix and aspirin is based on the individual patient's medical history, overall health, and the surgeon's assessment. The careful consideration of these factors ensures the optimal balance between preventing clot formation and minimizing potential side effects.