Question

Diagnosis: 78 year old female presents with memory loss, myoclonus, startle response, and seizures. Recently had a corneal transplant. What is the pathology ?

Answer 1

The 78-year-old female is likely exPOST ANSWER

periencing Creutzfeldt-Jakob disease (CJD), a neurodegenerative disease that affects the brain and can cause memory loss, myoclonus, startle response, and seizures. This disease is characterized by the presence of 14-3-3 protein in the CSF and abnormal brain function on an EEG.

Step-by-step explanation:

The 78-year-old female presents with memory loss, myoclonus, startle response, and seizures, along with a recent corneal transplant. These symptoms, along with the absence of inflammation or infection in the CSF samples, high concentration of 14-3-3 protein, and abnormal EEG, are indicative of Creutzfeldt-Jakob disease (CJD), a type of transmissible spongiform encephalopathy. CJD is a rare neurodegenerative disease that affects the brain and can cause cognitive decline, myoclonus, and seizures.