Final answer:
An advantage of NSAIDs with COX-2 selectivity is a potentially reduced risk of causing stomach problems while providing effective anti-inflammatory and pain-relief effects.
Step-by-step explanation:
An advantage of NSAIDs with COX-2 selectivity is that they may be less likely to cause stomach problems compared to traditional non-selective NSAIDs. This selective inhibition focuses on blocking the COX-2 enzyme, which is more directly involved in the inflammatory process, while sparing the COX-1 enzyme that helps protect the stomach lining. For instance, Celebrex (celecoxib), the only COX-2 selective inhibitor available in the United States, is designed to decrease the risk of gastrointestinal issues while still providing the anti-inflammatory and pain-relief effects.
Non-selective NSAIDs like aspirin inhibit both COX-1 and COX-2 enzymes, which can disrupt the protective mucous lining of the stomach, potentially leading to stomach problems. By being more selective, COX-2 inhibitors like celecoxib are developed to mitigate this risk. However, it's important to note that all NSAIDs carry some risk of stomach problems, and their use should be managed carefully.