134k views
2 votes
What is an advantage of NSAIDS WITH COX2 selectivity

User Ken Keenan
by
7.8k points

1 Answer

7 votes

Final answer:

An advantage of NSAIDs with COX-2 selectivity is a potentially reduced risk of causing stomach problems while providing effective anti-inflammatory and pain-relief effects.

Step-by-step explanation:

An advantage of NSAIDs with COX-2 selectivity is that they may be less likely to cause stomach problems compared to traditional non-selective NSAIDs. This selective inhibition focuses on blocking the COX-2 enzyme, which is more directly involved in the inflammatory process, while sparing the COX-1 enzyme that helps protect the stomach lining. For instance, Celebrex (celecoxib), the only COX-2 selective inhibitor available in the United States, is designed to decrease the risk of gastrointestinal issues while still providing the anti-inflammatory and pain-relief effects.

Non-selective NSAIDs like aspirin inhibit both COX-1 and COX-2 enzymes, which can disrupt the protective mucous lining of the stomach, potentially leading to stomach problems. By being more selective, COX-2 inhibitors like celecoxib are developed to mitigate this risk. However, it's important to note that all NSAIDs carry some risk of stomach problems, and their use should be managed carefully.

User Hegash
by
8.5k points