Final answer:
A nursing home must inform the prescriber prior to any therapeutic substitution and record this in the resident's medical records, following the prescriber's preferred communication method.
Step-by-step explanation:
A nursing home facility must notify the prescriber before each therapeutic substitution using a method of communication designated by the prescriber. This requirement ensures that any changes in medication are explicitly communicated and approved, maintaining patient safety and adherence to treatment protocols. The facility must also document the therapeutic substitution in the resident's medical records, providing a clear and accessible record of the medication administered and any changes made thereof.