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What must be written on a written prescription by a prescriber to prohibit generic substitution of a drug?

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Final answer:

A prescriber must write "Dispense as Written" or "DAW" on a prescription to prevent generic substitution.

Step-by-step explanation:

To prohibit generic substitution of a drug, a prescriber must write "Dispense as Written" or "DAW" on the prescription.

In some regions, there might be other specific terminology or checkboxes on a prescription form mandated by law that must be used to ensure the pharmacy dispenses the exact brand as prescribed. This directive ensures the patient receives the specified brand name medication, even when a cheaper generic alternative is available. It is the prescriber's responsibility to justify the need for a brand-name drug, often due to patient allergies, specific drug interactions, or a lack of a generic equivalent.

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