Final answer:
The earliest symptoms of digoxin toxicity are gastrointestinal, particularly nausea and vomiting, which may persist for 24-48 hours and lead to dehydration and changes in vital signs.
Step-by-step explanation:
The earliest sign/symptom of digoxin toxicity is often gastrointestinal in nature, with nausea and vomiting being common initial symptoms. These symptoms may be accompanied by diarrhea as well. Users of digoxin may experience these symptoms for about 24-48 hours, which can potentially lead to dehydration and affect blood pressure and heart rate. Visual disturbances such as blurred or yellow vision, known as xanthopsia, may also occur but are typically not the first symptoms to present.