Question

Administration with which of the following would increase serum concentrations of disopyramide? Select all that apply.

A) Amiodarone
B) Quinidine
C) Rifampin
D) Cimetidine
E) Erythromycin

Answer 1

The administration of amiodarone, cimetidine, and erythromycin would increase serum concentrations of disopyramide by inhibiting the enzymes responsible for its metabolism.

Step-by-step explanation:

Medications that inhibit the metabolism of disopyramide can increase serum concentrations of the drug. In the context of the question, the correct options that would increase serum concentrations of disopyramide are:

• Amiodarone
• Cimetidine
• Erythromycin

Amiodarone and erythromycin both inhibit the cytochrome P450 enzymes responsible for the metabolism of many drugs, including disopyramide. This inhibition can lead to increased levels of disopyramide in the blood.

Cimetidine, a histamine H2-receptor antagonist, has been known to inhibit hepatic cytochrome P450 enzymes, thus similarly possessing the potential to raise disopyramide serum concentrations.

Alternatively, Rifampin is an inducer of certain cytochrome P450 enzymes and would typically lower the serum concentrations of medications metabolized by these enzymes rather than increase them. Therefore, rifampin would not be expected to increase serum concentrations of disopyramide.