Final answer:
Histamine stimulates nociceptors resulting in itching. Histamine is released upon tissue injury, leading to inflammation and activation of nociceptors. Antihistamines can mitigate these effects by blocking histamine receptors.
Step-by-step explanation:
When histamine stimulates the nociceptors, this experience is manifested as itching rather than pain. Nociceptors, which are a type of sensory receptor, are responsible for transducing potentially damaging stimuli such as mechanical, chemical, or thermal input that exceeds a certain threshold. These stimuli, when strong enough, are perceived as pain. However, when stressed or damaged tissues release certain chemicals like histamine, they can also activate nociceptors. Upon tissue injury, mast cells degranulate to release histamine which causes vasodilation and leads to inflammation. As part of the inflammatory response, histamine can stimulate nociceptors, resulting in sensations such as itching. Antihistamines can be used to block the effects of histamine, thereby decreasing these sensations.