Final answer:
Central Command Fatigue is a form of muscle fatigue linked to reduced neural signals from the CNS, potentially due to neurotransmitter depletion, changes in cellular pH, damage to the SR and sarcolemma, or immune system attacks on the CNS as seen in multiple sclerosis.
Step-by-step explanation:
When discussing Central Command Fatigue, it is important to understand the role of neurons in the central nervous system (CNS). Central Command Fatigue refers to a state where muscle fatigue ensues due to a decrease in neural signals from the CNS to the muscles. The underlying cause of this decreased signaling can stem from a variety of factors, including the depletion of neurotransmitters, alterations in metabolic and enzyme activities due to changes in pH from lactic acid buildup, and potential damage to cellular structures like the sarcoplasmic reticulum (SR) and the sarcolemma.
Particularly noteworthy is the fact that the immune system can sometimes mistakenly target and damage the CNS, affecting neuronal function. This is exemplified by conditions like multiple sclerosis (MS), where the immune system attacks the myelin sheath that surrounds neurons, leading to a host of neurological symptoms such as fatigue. Additionally, neurons are also impacted by prolonged stress responses orchestrated by glucocorticoids, which alter energy utilization and conservation to ensure continued neural function.