Final answer:
Rho (D) Immune Globulin, or RhoGAM, should be injected into the deltoid muscle or anterolateral thigh of a postpartum Rh-negative client to prevent HDN. It is crucial to administer this treatment within 72 hours post-delivery.
Step-by-step explanation:
When administering Rho (D) Immune Globulin, commonly known as RhoGAM, to a postpartum client with Rh-negative blood type, the preferred injection sites are the deltoid muscle of the arm or the anterolateral aspect of the thigh. This immunoglobulin is crucial for preventing hemolytic disease of the newborn (HDN) caused by Rh incompatibility.
Administration typically occurs during the 28th week of pregnancy and again within 72 hours after delivery. Additional doses may be necessary following events that can lead to transplacental hemorrhage, such as miscarriage, abortion, or invasive prenatal testing. The strategic use of RhoGAM has significantly reduced the incidence of HDN by preventing the development of Rh antibodies in Rh-negative individuals exposed to Rh-positive blood, showcasing its importance in maternal and fetal health.