Final answer:
T-cell acute lymphoblastic leukemia (T-ALL) is caused by a mutation in the Notch signaling pathway and affects the growth and differentiation of T cells. Symptoms of T-ALL include fatigue, easy bruising and bleeding, frequent infections, and enlarged lymph nodes.
Step-by-step explanation:
T-cell acute lymphoblastic leukemia (T-ALL) is a type of cancer that affects T lymphocytes, a type of white blood cell. It is caused by a mutation in the Notch signaling pathway.
T-ALL is characterized by the uncontrolled growth of immature T cells, leading to the accumulation of these cells in the bone marrow and blood. Some common symptoms of T-ALL include fatigue, easy bruising and bleeding, frequent infections, and enlarged lymph nodes.
The Notch signaling pathway plays a crucial role in the development and differentiation of T cells. When this pathway is mutated, it disrupts the normal process of T cell maturation and leads to the development of T-ALL.