Final answer:
The Drug Enforcement Administration (DEA) has jurisdiction over the manufacture and distribution of controlled substances in the United States.
Step-by-step explanation:
The agency that has jurisdiction over the manufacture and distribution of controlled substances in the United States is the Drug Enforcement Administration (DEA). The DEA is a federal law enforcement agency that operates under the U.S. Department of Justice. Its primary responsibility is to enforce the controlled substances laws and regulations of the United States. The DEA works to prevent the diversion of controlled substances, investigates drug trafficking organizations, and targets individuals and organizations involved in the illegal manufacturing and distribution of controlled substances.