Final answer:
Systemic manifestations of inflammation include elevated C-reactive protein and leukocytosis, which are indicative of the body-wide presence of inflammation and immune system activity.
Step-by-step explanation:
The systemic manifestations of an inflammatory response may include a number of signs and symptoms. Among them, the presence of elevated C-reactive protein and leukocytosis are systemic or body-wide indicators. These phenomena are not merely localized to the area of infection or injury but reflect broader biological processes. Elevated C-reactive protein is a marker of inflammation present throughout the body, and leukocytosis refers to an increased number of white blood cells in the blood, often in response to infection, inflammation, or other conditions.
While localized inflammation may present with erythema (redness), edema (swelling), heat, pain, and sometimes altered function, systemic indicators such as elevated C-reactive protein and leukocytosis reflect the activity of the immune system on a larger scale. These markers might be observed and measured through blood tests, providing clinicians with insights into the intensity and spread of the inflammatory response.