Final answer:
The most significant factor in how individuals cope with an unexpected hospitalization is their perception of the hospitalization.
Step-by-step explanation:
The most significant factor in how individuals cope with an unexpected hospitalization is the client's perception of the hospitalization. This is because an individual's perception can greatly impact their emotional and psychological well-being during the hospital stay. If the client has a positive perception and feels in control of their situation, they are more likely to cope effectively and adapt to the challenges they may face. On the other hand, a negative perception can lead to increased stress and difficulty in coping.