Final answer:
Discrimination based on protected classes is the most significant factor in determining liability around EEO claims.
Step-by-step explanation:
When determining liability around EEO claims, the factor with the greatest significance is discrimination based on protected classes. The U.S. Equal Employment Opportunity Commission (EEOC) enforces federal laws that make it illegal to discriminate against job applicants or employees based on race, color, religion, sex, sexual orientation, national origin, age, disability, or genetic information. Discrimination based on protected classes is a key factor in determining liability in EEO claims.