Final answer:
In an uncomplicated case of infectious mononucleosis, white blood cells, specifically T-helper cells and monocytes, are the cells that are most affected.
Step-by-step explanation:
In an uncomplicated case of infectious mononucleosis, the white blood cells are the cells that are most affected.
Specifically, the T-helper cells and monocytes are the white blood cells that are commonly affected by the Epstein-Barr virus or Cytomegalovirus.