Final answer:
Giemsa stain is closely associated with the lysosomal enzyme in primary (azurophilic) granules.
Step-by-step explanation:
The stain closely associated with the lysosomal enzyme in primary (azurophilic) granules is Giemsa stain.
Giemsa stain is commonly used in histology and cytology to visualize and differentiate cellular components. It is particularly effective in staining the lysosomal enzymes in primary granules of neutrophils, which are involved in the immune response.