Question

Of the following, the disease most closely associated with granulocyte hyposegmentation is?

1) Leukemia
2) Sickle cell anemia
3) Pelger-Huet anomaly
4) Multiple myeloma

Answer 1

The Pelger-Huet anomaly is the condition most closely associated with granulocyte hyposegmentation, affecting the segmentation of neutrophil nuclei.

Step-by-step explanation:

The disease most closely associated with granulocyte hyposegmentation is the Pelger-Huet anomaly. This is a rare inherited condition where granulocytes display abnormal nuclear shape and chromatin structure, reducing the number of lobes typically observed in the nuclei of neutrophils. Among the provided options, which include (Leukemia, Sickle cell anemia, Pelger-Huet anomaly, and Multiple myeloma), option 3, Pelger-Huet anomaly, is the correct answer.

Granulocytes are a type of leukocyte characterized by the presence of granules in their cytoplasm and a lobed nucleus. They include neutrophils, eosinophils, and basophils, which are all produced in the red bone marrow and have a relatively short lifespan. The Pelger-Huet anomaly specifically affects the segmentation of neutrophil nuclei, a key characteristic of their maturation process.