Final answer:
Verapamil is the calcium channel blocker with the greatest physiological effect.
Step-by-step explanation:
The calcium channel blocker that has the greatest physiological effect is Verapamil. Verapamil belongs to a class of drugs known as calcium antagonists or calcium channel blockers, which are used in the treatment of various cardiovascular conditions.
Verapamil works by blocking calcium channels in the heart and blood vessels, resulting in reduced calcium influx and relaxation of smooth muscle.