Final answer:
Metastasized cancer site sequencing depends on treatment goals and patient health. Sequencing the metastatic site could guide targeted therapies if it is causing significant symptoms or is the focus of care. More information on the patient's condition is required to make a definitive recommendation.
Step-by-step explanation:
Whether the metastasized cancer site should be sequenced first if it is the primary focus of care depends on various clinical factors, including the treatment goals, the type of cancer, the extent of metastasis, and overall patient health. Cancer requires multiple mutations and when it metastasizes, treatment becomes more complex. Usually, treatment focuses on controlling the cancer's spread and managing symptoms rather than primarily seeking curative outcomes. Since metastasis indicates that the cancer has spread beyond local tissue, understanding the genomic profile of the metastatic site can influence the treatment plan. Treatment decisions are typically coordinated by a multi-disciplinary team based on a comprehensive assessment of the patient's condition.
In this case, more information about the patient's specific circumstances and overall treatment strategy would be needed to specifically answer whether the metastasized site should be sequenced first. Often, the primary tumor is sequenced, but if the metastatic site is causing significant symptoms or is the current focus of care, it may be sequenced preferentially to guide targeted therapies or other interventions.