Final answer:
Aminoglycosides kill bacteria by binding to the 30S ribosomal subunit, impairing proofreading which leads to faulty proteins, and disrupting the bacterial cytoplasmic membrane, ultimately causing cell death.
Step-by-step explanation:
The three major actions by which aminoglycosides kill bacteria are aminoglycosides like streptomycin, gentamicin, neomycin, and kanamycin are broad-spectrum antibacterials that interfere with bacterial protein synthesis. This interference results in proteins with incorrect amino acids and shortened proteins that can disrupt the bacterial cell membrane and induce cell death. However, it is worth noting that aminoglycosides can have serious side effects such as nephrotoxicity, neurotoxicity, and ototoxicity.