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Which cell lineage do follicular lymphomas arise from?

1) B cells
2) T cells
3) Natural killer cells
4) Stem cells

1 Answer

1 vote

Final answer:

Follicular lymphomas originate from B cells, which are a type of lymphocyte that matures in the bone marrow and is responsible for antibody production as part of the adaptive immune system.

Step-by-step explanation:

Follicular lymphomas arise from a specific lineage of lymphocytes. The cell lineage from which follicular lymphomas develop is the B cells. This is based on the biology of lymphocytes and the nature of this type of cancer. Lymphoid stem cells migrate from the bone marrow to lymphatic tissues like the lymph nodes and spleen, where they become differentiated into various types of lymphocytes, including B cells, T cells, and NK (natural killer) cells. Specifically, B cells mature within the bone marrow itself. These cells are a critical component of the adaptive immune system and function by producing antibodies.

When activated by antigen exposure, B cells can differentiate into plasma cells that secrete antibodies, being part of the specific immune response. The transformation of these B cells can sometimes go awry, resulting in the development of follicular lymphomas, a type of cancer in which masses of malignant B lymphocytes accumulate in lymphatic tissues. Thus, option 1) B cells, is the correct answer to the question regarding the cell lineage for follicular lymphomas.

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