Final answer:
The transformation from chronic lymphocytic leukemia to diffuse, large B-cell lymphoma is known as Richter transformation and signifies a shift from a slower-growing leukemia to a more aggressive form of non-Hodgkin lymphoma.
Step-by-step explanation:
The transformation of chronic lymphocytic leukemia (CLL) into diffuse, large B-cell lymphoma (DLBCL) is called Richter transformation. This phenomenon occurs when CLL, which typically involves a more indolent or slow-growing form of cancer affecting B lymphocytes, evolves into a more aggressive form of non-Hodgkin lymphoma (NHL). DLBCL is a fast-growing, aggressive type of NHL that requires early detection and comprehensive treatment, including immunotherapy, chemotherapy, and radiation, to improve survival outcomes.