Final answer:
Severe pain with breathing is the least likely manner in which lung cancer will manifest.
Step-by-step explanation:
The LEAST likely manner in which lung cancer will manifest in a 65-year-old man with a long history of smoking tobacco is severe pain with breathing. While lung cancer can cause various symptoms, such as a nodule detected in a chest x-ray, a palpable mass in the chest, a productive cough, or the presence of blood in the sputum, severe pain with breathing is less commonly associated with lung cancer.