Final answer:
The initiation of transcription in eukaryotes is more complex than in prokaryotes, involving different RNA polymerases, initiation complex with enhancers and transcription factors, and histones for DNA strand separation.
Step-by-step explanation:
The initiation of transcription in eukaryotes is different from prokaryotes in several ways. First, eukaryotes use one of three different RNA polymerases, depending on the gene being transcribed. Second, the initiation step in eukaryotes requires an initiation complex with enhancers and transcription factors, which bind to complex promoter sequences upstream of the gene. Third, the DNA strand separation in eukaryotes involves histones. These differences in initiation of transcription make it more complex in eukaryotes compared to prokaryotes.