Final answer:
Infectious mononucleosis, typically caused by the Epstein-Barr virus, can lead to an enlarged spleen and increase the risk of splenic rupture, which is a serious complication.
Step-by-step explanation:
Infectious mononucleosis is indeed associated with an increased risk for splenic rupture. Infectious mononucleosis, which is often caused by the Epstein-Barr virus (EBV), can lead to enlargement of the spleen. In the second or third week of the infection, when abdominal pain might occur due to the enlargement of spleen and liver, there is a risk for splenic rupture, which can be a serious complication. Therefore, individuals with infectious mononucleosis are advised to avoid contact sports or activities that may cause abdominal trauma to prevent the risk of splenic rupture.