Final answer:
The statement is true. EBV infection can lead to spleno-megaly due to the activation and proliferation of CD8+ T-cells in response to the viral infection.
Step-by-step explanation:
The statement that the Cd₈⁺ T-cell response in EBV infection leads to spleno-megaly is True.
EBV infection, also known as infectious mononucleosis, can cause enlargement of the spleen. This occurs due to the activation and proliferation of CD8+ T-cells in response to the viral infection. The increased number of CD8+ T-cells can lead to spleno-megaly, which is the enlargement of the spleen.
For example, during an EBV infection, the CD8+ T-cells recognize and destroy infected B-cells, which contributes to the immune response against the virus. However, the excessive activation and expansion of CD8+ T-cells can lead to the enlargement of the spleen.