Final answer:
Anencephaly is a severe neural tube defect that causes various physical characteristics, including a 'frog-like' appearance with prominent eyes. Other associated physical features include an enlarged head, cleft lip and palate, low-set ears, and webbed fingers and toes.
Step-by-step explanation:
Anencephaly is a severe neural tube defect that affects the development of the brain and skull. In addition to the 'frog-like' appearance caused by prominent eyes, other physical characteristics commonly associated with anencephaly include an enlarged head, cleft lip and palate, low-set ears, and webbed fingers and toes. These physical characteristics result from the improper development of the neural tube during early embryonic development.