Question

A client is administered mesna to prevent cystitis induced by ifosfamide. mesna will prevent what adverse effect?

A) Cardiotoxicity
B) Hepatotoxicity
C) Nephrotoxicity
D) Hematologic toxicity

Answer 1

Mesna is used to prevent hemorrhagic cystitis, which is a form of hematologic toxicity arising from ifosfamide treatment. It protects the bladder by binding to toxic metabolites of ifosfamide. so, option D is the correct answer.

Step-by-step explanation:

The client is administered mesna to prevent hemorrhagic cystitis induced by ifosfamide. Mesna will prevent adverse effect (D) Hematologic toxicity. Hemorrhagic cystitis is a condition where the lining of the bladder becomes inflamed and begins to bleed, which can be a side effect of chemotherapy drugs such as ifosfamide. Mesna works by binding to the toxic metabolites of ifosfamide that cause bladder irritation and facilitates their excretion in the urine, thereby protecting the bladder from injury.

The client is administered mesna to prevent cystitis induced by ifosfamide. Mesna is a chemoprotective agent that works by binding to and detoxifying the toxic metabolites of ifosfamide in the bladder. By preventing the accumulation of toxic metabolites, mesna helps to prevent nephrotoxicity or kidney damage, which is an adverse effect of ifosfamide treatment.