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a woman is blood type o and rh- and her husband is blood type ab and rh . what are the possible genotypes of their offspring in terms of abo blood group?

User Jon Reid
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Final answer:

Children of a mother with blood type O (ii) Rh- and a father with blood type AB Rh+ can have either type A (IAi) or type B (IBi) blood. The mother can donate blood to her husband, but the husband, if Rh+, should not donate to his Rh- wife. An O type child can have parents with blood types A and B.

Step-by-step explanation:

Possible Offspring Blood Types from Parents with O Rh- and AB Rh+ Blood Types

When considering a mother with blood type O (genotype ii) and Rh- and a father with blood type AB (genotype can be IAIB) and Rh+, the offspring can have either type A or type B blood. They will inherit the 'i' allele from the mother and either the IA or IB allele from the father. Therefore, the possible genotypes for the offspring are IAi for type A blood or IBi for type B blood.

Regarding the Rh factor, since the father is Rh+, he could be either homozygous (Rh+Rh+) or heterozygous (Rh+Rh-). If he is heterozygous, there's a chance that the offspring could also be Rh-. Consequently, the offspring could be Rh+ (having at least one Rh+ allele) or Rh- (if they inherit the Rh- allele from both parents). However, without knowing the father's exact genotype for the Rh factor, we cannot determine the exact possibilities for Rh typing.

Blood Donation between the Mother and Father

The mother, being blood type O Rh-, can donate blood to her husband as blood type O is considered a universal donor for red blood cells, and Rh- blood can be given to both Rh+ and Rh- recipients. On the other hand, the husband cannot donate blood to his wife if he is Rh+ because the Rh antigen could provoke an immune response in the Rh- wife, potentially leading to sensitization.

Answering a related question, an individual with blood type O (ii) can indeed be a child of parents with blood types A (AO or AA) and B (BO or BB), because both parents can contribute the recessive 'i' allele.

User Gaurav Shah
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