Final answer:
A low-grade fever is a clinical manifestation associated with tuberculosis, along with symptoms like persistent cough, night sweats, and loss of appetite. Therefore, the correct option is D.
Step-by-step explanation:
The clinical manifestation associated with tuberculosis (TB) is low-grade fever. Tuberculosis is a disease caused by Mycobacterium tuberculosis and primarily affects the lungs, although it can impact other areas of the body. The common symptoms of active TB include persistent cough, night sweats, loss of appetite, weight loss, and low-grade fever. These symptoms can be similar to other diseases like influenza, bronchitis, and pneumonia, making diagnosis challenging without appropriate testing.