Final answer:
Lake Manitoba is located in Canada.
Step-by-step explanation:
The correct answer is D. Lake Manitoba.
Located in central Canada, Lake Manitoba is one of the largest lakes in the country. It is situated in the province of Manitoba and is a significant geographical feature of the region.
The other options listed in the question are not located in Canada. Mount Rushmore is a famous monument in the United States, the Erie Canal is a waterway in New York State, and the Mississippi River is a major river in the United States.