Final answer:
The statement is true; megaloblastic anemia affects all rapidly dividing cells, including intestinal epithelial cells, due to impairments in DNA synthesis caused by deficiencies in vitamin B12 and/or folate.
Step-by-step explanation:
The statement that megaloblastic anemia also leads to megaloblastic change in cells that are rapidly-dividing, such as intestinal epithelial cells, is True. Megaloblastic anemia is typically caused by a deficiency of vitamin B12 and/or folate. This type of anemia is characterized by the presence of abnormally large red blood cells (RBCs) with immature nuclei due to impaired DNA synthesis.
Because folate and vitamin B12 are essential for DNA synthesis, their deficiencies affect all rapidly dividing cells in the body, not just the erythroblasts in bone marrow. This includes the cells of the gastrointestinal tract, such as the intestinal epithelial cells. Furthermore, since the intestinal epithelial cells have a high turnover and divide quickly, they would exhibit similar megaloblastic changes when there is a deficiency in these vital nutrients.