Question

α-thalassemia due to a three gene deletion is characterized by the formation of β4 tetramers, known as HbH. HbH tetramers may damage RBCs, thus causing severe anemia, also known as 'H bodies'. True or False?

Answer 1

True. α-thalassemia due to a three gene deletion results in the formation of β4 tetramers, also known as HbH, which can damage red blood cells (RBCs) and cause severe anemia, known as 'H bodies'.

Step-by-step explanation:

True. α-thalassemia due to a three gene deletion results in the formation of β4 tetramers, also known as HbH. These HbH tetramers can damage red blood cells (RBCs) and cause severe anemia, known as 'H bodies'.

HbH is formed when the beta chain combines with itself due to the lack of alpha chains. This abnormal hemoglobin impairs the transport of oxygen by RBCs, leading to hypoxia and anemia. Additionally, the life span of RBCs affected by HbH is significantly reduced.

Therefore, the statement that HbH tetramers can damage RBCs, causing severe anemia or 'H bodies,' is true.