Final answer:
Option (E), Skin regeneration after significant damage is effective due to the presence of stem cells in the stratum basale that produce new cells, alongside the actions of fibroblasts and immune cells which repair tissue and prevent infection.
Step-by-step explanation:
Skin can regenerate effectively even after considerable damage has occurred primarily because stem cells persist in the skin even after injury. These stem cells, particularly those found in the stratum basale, continuously undergo cell division to produce new keratinocytes, which are the main cells of the epidermis.
Furthermore, fibroblasts in the dermis play a crucial role in wound healing by mobilizing and dividing rapidly to repair the damaged tissue through collagen deposition, forming granulation tissue which is followed by increased blood circulation thanks to the development of new blood capillaries, enhancing oxygen supply to the damaged area. Immune cells like macrophages also contribute to the wound healing process by removing debris and reducing the risk of infection.