Final answer:
The primary entry for Aspergillus is the respiratory tract, especially in cases of secondary cutaneous aspergillosis, where the infection spreads from the respiratory system to the rest of the body.
Step-by-step explanation:
The major portal of entry for Aspergillus is the respiratory tract. In cases of secondary cutaneous aspergillosis, the fungus initially enters the body via the respiratory system and may then disseminate to other parts of the body, including the skin. However, in primary cutaneous aspergillosis, which is less common, infection begins with a direct invasion of the skin, usually through a wound. Nonetheless, the primary route for Aspergillus infection, leading to conditions such as pulmonary aspergillosis, is through inhalation and the respiratory system.