Final answer:
The statement about the splicing of pre-mRNA via a spliceosome that is false is that U1 snRNP binds to the 3' splice site (Option E).
Step-by-step explanation:
The incorrect statement regarding pre-mRNA splicing is that U1 snRNP binds to the 3' splice site, while it actually binds to the 5' splice site. The correct sequence of events during the splicing process is that U1 snRNP binds to the 5' splice site of the pre-mRNA. U2 snRNP does bind to the branch site, and a trimer consisting of U4/U6 and U5 snRNP does indeed bring the exons closer together.
Furthermore, the intron is released in the form of a lariat after the 5' splice site is cut first, followed by the 3' splice site being cut. Therefore, the incorrect statement is that U1 snRNP binds to the 3' splice site when, in fact, it binds to the 5' splice site.
Thus, the correct option is E.
Your question is incomplete, but most probably your full question was
All of the following statements about the splicing of pre-mRNA via a spliceosome are true except one. Which one?
a) A trimer consisting of U4/U6 and U5 brings the exons closer together.
b) U2 snRNP binds to branch site.
c) The 5' splice site is cut prior to the cutting of the 3' splice site.
d) The intron is released in the form of a lariat.
e) U1 snRNP binds to the 3' splice site.