Question

Transmissible spongiform encephalopathies (TSEs) are a family of fatal brain diseases that can affect both humans and animals. These diseases are typically characterized by protein aggregates forming esions that look like small cavities. __________ is an example of a human TSE.

Answer 1

Creutzfeldt-Jakob disease is an example of a transmissible spongiform encephalopathy in humans. It is caused by prions leading to fatal neurodegeneration, and currently, there is no cure for such diseases.

Step-by-step explanation:

Transmissible spongiform encephalopathies (TSEs) are a group of fatal, degenerative neurological diseases caused by acelluar infectious agents known as prions. These diseases, which affect both humans and animals, are characterized by protein aggregates forming lesions and cavities that give brain tissue a spongy appearance. In humans, TSEs include a variety of diseases such as kuru, fatal familial insomnia, Gerstmann-Straussler-Scheinker disease, and Creutzfeldt-Jakob disease (CJD).

One example of a human TSE is Creutzfeldt-Jakob disease. Prions, specifically the misfolded form known as PrPsc, lead to an accumulation of rogue proteins that cause the death of brain cells, resulting in memory loss, personality changes, and a rapid progression towards dementia and death. Unfortunately, there is no cure for TSEs, and medical support mainly aims to provide comfort for patients.