Question

"RAG1 and RAG2 proteins are associated with which of the following?

a)Recombination during prophase 1 of meiosis
b)Nucleotide excision repair
c)Transposition
d)Integration of a bacteriophage into the host genome
e)Site-specific recombination in antibody genes"

Answer 1

RAG1 and RAG2 proteins are crucial for site-specific recombination in the generation of diverse antibody genes during B cell maturation.

Step-by-step explanation:

The RAG1 and RAG2 proteins are associated with site-specific recombination in antibody genes. These proteins play a crucial role in the immune system by contributing to the diversity of antibodies. This process, known as V(D)J recombination, involves the random excision and recombination of Variable (V), Diversity (D), and Joining (J) segments of immunoglobulin genes during the maturation of B cells in the bone marrow. The rearrangement of these segments leads to the production of a wide array of antibodies, each with a unique variable region that can bind to a different antigen. This mechanism is crucial for the immune system's ability to recognize and combat a vast variety of pathogens.