Question

The levels of TBG and total thyroid hormone are decreased with hepatic failure, steroid use, and nephrotic syndrome, due to decreased TBG synthesis by the liver. How is decreased TBG detected?

1) Increased resin uptake
2) Decreased resin uptake
3) Increased TBG synthesis
4) Decreased TBG synthesis

Answer 1

Decreased TBG levels are detected by increased resin uptake.

Step-by-step explanation:

Decreased TBG levels are detected by increased resin uptake.

Answer 2

Decreased TBG is detected by 4) Decreased TBG synthesis.

Step-by-step explanation:

Thyroid-binding globulin (TBG) is a protein produced by the liver that binds to thyroid hormones in the blood. Conditions such as hepatic failure, steroid use, and nephrotic syndrome can lead to decreased TBG levels due to reduced synthesis in the liver. Therefore, the correct option is 4) Decreased TBG synthesis. In such cases, less TBG is available to bind with thyroid hormones, resulting in lower total thyroid hormone levels. The other options are not directly related to detecting decreased TBG; resin uptake tests primarily measure thyroid hormone binding, not TBG levels, and increased TBG synthesis is not characteristic of these conditions.

Option 4 is the answer.