Final answer:
Patients with ataxia, opsoclonus-myoclonus should be tested for (c) anti-Hu antibodies to check for paraneoplastic syndrome (c) , which is linked to underlying cancers. The anti-Hu antibodies and examination of CSF can provide critical diagnostic information for paraneoplastic syndromes and differentiate from other neurological diseases.
Step-by-step explanation:
Patients with ataxia, opsoclonus-myoclonus should be tested with anti-Hu antibodies for possible paraneoplastic syndrome. When a patient presents with symptoms like ataxia and opsoclonus-myoclonus, it raises the concern for a paraneoplastic neurological syndrome, which might be associated with an underlying malignancy. Testing for anti-Hu antibodies in the blood can help diagnose the condition as these antibodies are often present in paraneoplastic syndromes linked to certain types of cancer, such as small cell lung cancer.
Additionally, analyzing cerebrospinal fluid (CSF) through lumbar puncture can provide valuable diagnostic information for various neurological conditions. It helps assess for inflammation, infection, and the presence of specific proteins such as oligoclonal bands - indicating an inflammatory or demyelinating process in the central nervous system. In the case of Cora, mentioned in the reference materials, finding a high concentration of 14-3-3 protein in CSF and an abnormal EEG led to a diagnosis of Creutzfeldt-Jakob disease, not neuroblastoma.