Final answer:
Splenic sequestration in sickle cell disease is best treated with hydration and blood transfusions to manage acute complications. Splenectomy may be considered in recurrent cases. Platelet transfusions and antibiotics are not standard treatments for this condition.
Step-by-step explanation:
Splenic sequestration is a complication of sickle cell disease in which sickle-shaped red blood cells are trapped in the spleen leading to a sudden drop in hemoglobin levels and the potential for rapid enlargement of the spleen. The appropriate treatment for significant splenic sequestration associated with sickle cell disease is c) Hydration and blood transfusions. Hydration helps to improve blood flow and blood transfusions are necessary to increase the number of normal red blood cells and improve oxygen delivery to the tissues. While in some cases, particularly if a patient experiences recurrent episodes of splenic sequestration, surgical removal of the spleen (splenectomy) may be considered, acute episodes are primarily managed with hydration and transfusions. Antibiotics are not typically used for the treatment of splenic sequestration unless there is a concurrent infection, and platelet transfusions are not indicated for this condition.