Question

Splenic sequestration in sickle cell disease is a medical emergency and can:

a) Be managed conservatively
b) Lead to hypoglycemia
c) Cause rapid and severe anemia
d) Result in kidney dysfunction

Answer 1

Splenic sequestration in sickle cell disease can cause rapid and severe anemia and typically requires immediate medical attention rather than conservative management. It is unrelated to hypoglycemia or kidney dysfunction but severe anemia can affect various organs.

Step-by-step explanation:

Splenic sequestration in sickle cell disease is indeed a medical emergency, which occurs when sickle-shaped red blood cells (erythrocytes) block blood flow to the spleen, leading to the spleen's rapid enlargement. This can cause a substantial decrease in circulating red blood cells, thereby causing rapid and severe anemia.

Managing this condition often requires immediate medical attention and may include transfusions to reduce the risk of life-threatening complications. Splenic sequestration is not typically associated with conservative management except as a bridge to more definitive treatment, nor does it directly cause hypoglycemia or kidney dysfunction, although severe anemia can indirectly affect many organs in the body.