Final answer:
Spironolactone does not have an adverse interaction with antacids, unlike tetracycline and ciprofloxacin, which can have their absorption affected.
Step-by-step explanation:
The drug among the listed options that does not have an adverse interaction with antacids is C. Spironolactone. Antacids are known to interact with certain antibiotics by affecting their absorption and bioavailability. Specifically, tetracycline and drugs similar to it, such as doxycycline and minocycline, are known to bind with the components of antacids, which can reduce their effectiveness. Ciprofloxacin, a fluoroquinolone antibiotic, can also have its absorption reduced when taken with antacids. Spironolactone, on the other hand, is a potassium-sparing diuretic used primarily to treat conditions like heart failure and high blood pressure, and it does not have this interaction with antacids.