Question

In a patient with sickle cell disease, which of the following bacterial agents is a common cause of osteomyelitis?

A) Staphylococcus
B) Shigella
C) E. Coli
D) Salmonella
E) Streptococcus

Answer 1

Salmonella species are a common cause of osteomyelitis in patients with sickle cell disease, differing from the general population where Staphylococcus aureus is more common. This is due to the unique environment in infarcted bone that favors Salmonella's growth in sickle cell patients.

Step-by-step explanation:

In patients with sickle cell disease, Salmonella species, rather than Streptococcus, are commonly associated with osteomyelitis. This condition, an inflammation of bone tissue, can be caused by various bacteria. However, individuals with sickle cell disease have a predisposition to infections with Salmonella due to the infarction of bone caused by sickled cells leading to a potential habitat for Salmonella.

Although Staphylococcus aureus is the most common causative agent of osteomyelitis in the general population, within the context of sickle cell disease, infarctions create a unique environment that promotes the growth of Salmonella. It is important for healthcare professionals to be aware of this distinction when diagnosing and treating osteomyelitis in patients with sickle cell disease to ensure appropriate antibiotic therapy is administered.