Final answer:
Non-disease factors affecting ESR include hemoglobin concentration, erythropoiesis alterations like polycythemia or anemia, liver function impairments, dehydration, and abnormal levels of leukocytes, platelets, or erythropoietin.
Step-by-step explanation:
Some non-disease factors that affect Erythrocyte Sedimentation Rate (ESR) include hemoglobin concentration and blood viscosity. Conditions that alter erythropoiesis such as polycythemia or anemia can change blood viscosity due to the volume percentage of red blood cells affecting it. Additionally, conditions that impair liver function leading to altered production of plasma proteins can slightly change blood viscosity, influencing ESR as well.
Dehydration can also cause a temporary increase in RBC count, falsely indicating polycythemia, which raises the viscosity of blood.
Moreover, extreme increases in leukocytes or platelets, though rare, can impact blood viscosity. Elevated levels of erythropoietin, especially through synthetic means, can similarly increase blood viscosity, affecting ESR.