Final answer:
Megaloblastic anemia, caused by vitamin B12 and/or folate deficiencies, results in macrocytic anemia with larger-than-normal red blood cells, making the statement True.
Step-by-step explanation:
Megaloblastic anemia is indeed a cause of macrocytic anemia, which is characterized by an increased mean corpuscle volume (MCV). This type of anemia is generally caused by deficiencies in vitamin B12 and/or folate, essential nutrients for the proper formation and maturation of red blood cells (RBCs). These deficiencies can be attributed to various dietary habits such as lack of meat, insufficient intake of vegetables, or overcooking them. It can also result from conditions that impair nutrient absorption, such as Crohn's disease, pernicious anemia, or following certain surgeries. The reduction in RBC production leads to larger-than-normal cells, referred to as macrocytic, thus the statement is True.