Final answer:
α-thalassemia with one gene deleted presents as a result of decreased synthesis of the α-chain of globin, which occurs due to the absence of one gene. The severity of the condition can vary, from mild anemia to more severe symptoms such as anemia, pale skin, fatigue, and enlargement of the spleen.
Step-by-step explanation:
α-thalassemia with one gene deleted presents as a result of decreased synthesis of the α-chain of globin, which occurs due to the absence of one gene. As a result, the beta chain may combine with other chains such as gamma or beta itself, forming different types of hemoglobin structures. The presentation of α-thalassemia with one gene deleted can vary, depending on the severity of the condition. It can range from mild anemia to a condition called hemoglobin H disease, which can cause more severe symptoms such as anemia, pale skin, fatigue, and enlargement of the spleen.