Question

Loss of membrane blebs in hereditary spherocytosis renders RBCs round (spherocytes) instead of disc-shaped. What is the effect of loss of membrane blebs in hereditary spherocytosis on the shape of RBCs?

1) They become round (spherocytes)
2) They become disc-shaped
3) They become elongated
4) They become irregularly shaped

Answer 1

The loss of membrane blebs in hereditary spherocytosis causes RBCs to1. become round, also known as spherocytes, which leads to a propensity for destruction and anemia.

Step-by-step explanation:

The effect of loss of membrane blebs in hereditary spherocytosis on the shape of RBCs is that they become round, also known as spherocytes. Normally, erythrocytes have a biconcave disc shape, which optimizes the ratio of surface area to volume, facilitating efficient gas exchange and enabling them to fold and move through narrow blood vessels. Hereditary spherocytosis is a condition where there is a loss of part of the erythrocyte membrane, leading to a spherical shape. This shape can cause the red blood cells to be more prone to destruction in the spleen, leading to anemia and other related symptoms.

The loss of membrane blebs in hereditary spherocytosis causes a change in the shape of red blood cells (RBCs). Instead of being disc-shaped, the RBCs become round, or spherocytes. This is because the loss of membrane blebs disrupts the structural integrity of the RBCs, making them less flexible and unable to maintain their normal shape.