Question

When exposed to conditions that favor the taut form of Hemoglobin, HbS polymerizes and forms needle-like structures ("sickle cells"). Which of the following conditions favor oxygen unloading and can cause the formation of long chain polymers of HbS?

1) Ex Deoxygenation
2) High Altitude
3) Acidosis
4) Infection
5) Dehydration

Answer 1

Conditions that favor oxygen unloading and can cause the formation of long chain polymers of HbS (sickle cells) include ex deoxygenation, acidosis, and dehydration.

Step-by-step explanation:

The conditions that favor oxygen unloading and can cause the formation of long chain polymers of HbS (sickle cells) are:

1. Ex Deoxygenation: When hemoglobin is deoxygenated, it is more likely to polymerize and form sickle cells.
2. Acidosis: Acidic conditions in the body can promote the polymerization of HbS.
3. Dehydration: When the body is dehydrated, the concentration of hemoglobin increases, leading to an increased likelihood of polymerization.